journal articles
HEALTHY LIFESTYLE AND ALZHEIMER’S DISEASE IN INDIVIDUALS WITH HYPERLIPIDEMIA: A PROSPECTIVE COHORT STUDY
Danyang Sun, Linling Yu, Chenqi Liao, Yuzhong Xu, Wei Liu, Xiong Wang
BACKGROUND: Whether healthy lifestyle behaviors are associated with Alzheimer’s disease (AD) risk among individuals with hyperlipidemia remains unclear.
METHODS: We analyzed 241,642 dementia-free participants from the UK Biobank. A weighted lifestyle score (0–7) was derived from seven factors and categorized into five tiers. Hyperlipidemia was defined as lipid-lowering medication use or LDL-cholesterol ≥ 4.0 mmol/L. Cox regression estimated hazard ratios (HRs) and 95% confidence intervals (CIs).
RESULTS: Over a median follow-up of 14.5 years, 1728 AD cases occurred, including 977 cases among 104,082 individuals with hyperlipidemia. Compared with the intermediate tier, unhealthy lifestyle was associated with elevated AD risk (HR: 1.17; 95% CI: 1.02–1.35), while healtshy and very healthy tiers were associated with progressively lower risk (HR=0.85 and 0.74, respectively). These associations were evident among individuals with hyperlipidemia, but not statistically significant among those without hyperlipidemia.
CONCLUSIONS: Healthy lifestyle patterns were associated with lower AD risk among individuals with hyperlipidemia, with greater risk reductions observed for healthier lifestyle tiers.
CITATION:
Danyang Sun ; Linling Yu ; Chenqi Liao ; Yuzhong Xu ; Wei Liu ; Xiong Wang (2026): Healthy lifestyle and Alzheimer’s disease in individuals with hyperlipidemia: A prospective cohort study. The Journal of Prevention of Alzheimer’s Disease (JPAD). https://doi.org/10.1016/j.tjpad.2026.100520