journal articles
A NOVEL EARLY IMAGING BIOMARKER FOR GLYMPHATIC FUNCTION: CEREBRAL CORTICAL ARTERIAL PULSATILITY INDEX FROM 2-MINUTE PHASE-CONTRAST MRI
Sung-Hye You, Byungjun Kim, Byungjun Kim, Kyung-Sook Yang, Hye-Won Park, InSeong Kim, SuGil Kim, Kyung Min Kim, Bo Kyu Kim, Jae Ho Shin
BACKGROUND: Arterial pulsatility is one of the driving forces of glymphatic flow.
OBJECTIVES: To evaluate the feasibility of the pulsatility index (PI) of cortical arteries in the centrum semiovale (PICSO) as a novel non-invasive imaging biomarker for Alzheimer’s disease (AD) in the context of glymphatic function.
DESIGN: Retrospective cross-sectional study.
SETTING: Single tertiary academic center equipped with both 3.0 T MRI systems.
PARTICIPANTS: A total of 160 individuals were enrolled: 50 healthy volunteers, 46 cognitively normal controls, and 64 AD patients who underwent diffusion tensor imaging (DTI) and 2D phase-contrast MRI.
MEASUREMENTS: Diffusion Tensor Imaging Analysis along the Perivascular Space (DTI-ALPS) index and PICSO were assessed using 2D phase-contrast MRI. Correlations with age, DTI-ALPS index, and Mini-Mental State Examination (MMSE) scores were analyzed.
RESULTS: PICSO was significantly higher in the AD group than those in healthy volunteers (P<0.001) and cognitively normal aging (P=0.001) groups. PICSO correlated positively with age (rho=0.613, P<0.001) and negatively with both the DTI-ALPS index (rho=-0.439, P<0.001) and MMSE scores (rho=-0.486, P<0.001) in total group.
CONCLUSION: PICSO derived from 2D phase-contrast 3.0T MRI may serve as a novel imaging biomarker for Alzheimer’s disease in relation to glymphatic function.
CITATION:
Sung-Hye You ; Byungjun Kim ; Moonjung Hwang ; Kyung-Sook Yang ; Hye-Won Park ; InSeong Kim ; SuGil Kim ; Kyung Min Kim ; Bo Kyu Kim ; Jae Ho Shin (2025): A novel early imaging biomarker for glymphatic function: Cerebral cortical arterial pulsatility index from 2-Minute phase-contrast MRI. The Journal of Prevention of Alzheimer’s Disease (JPAD). https://doi.org/10.1016/j.tjpad.2025.100323