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EFFECTS ON COGNITION OF BERRY, POMEGRANATE, GRAPE AND BIOPHENOLS: A GENERAL REVIEW

L. Al Damen, A. Stockton, E.A.S. Al-Dujaili

Decline in cognitive function can be observed in normal aging, MCI, neurodegenerative disorders, cerebral hypoperfusion and post-surgery. Cognitive impairment presents with limited therapeutic options. Berries, pomegranates and grapes are polyphenol-rich fruits that have both antioxidant and anti-inflammatory effects. This review aims to explore the effects of these fruits and their biophenols on cognitive function in healthy subjects and their protective effects on cognitive deficits in normal aging, mild cognitive impairment, Alzheimer’s disease (AD), cerebral hypoperfusion using both animal models and human studies. MEDLINE® and Proquest Central data bases were searched to retrieve articles used in this general review according to specific inclusion criteria. Independently, two researchers have summarized the study characteristics and assessed quality of methodology. Meta-analysis was not possible due to the limited number of studies and marked heterogeneity, and thus results were presented as a narrative review. Biophenol-rich fruits have been shown to exert cognitive functions boosting and enhanced memory in children and healthy adults. In patients with age related cognitive decline, MCI and AD, Biophenols-rich fruits showed a marked enhancement of memory and verbal fluency with reduced dementia risk, and in artery graft and valve surgery, pomegranate protected against memory impairment. Animal studies have shown that biophenols intake enhanced cognition in AD models presumably due to a reduction of Amyloidβ plaque deposition, inflammatory cytokines, microgliosis (glial cells hypertrophy), and brain DNA protection. In conclusion, large scale studies are urgently needed to fully evaluate the preventive and/or adjunctive therapy of biophenol-rich fruits in cognitive decline, deficit and Alzheimer disease.

CITATION:
L. Al Damen ; A. Stockton ; E.A.S. Al-Dujaili ; (2018): Effects on Cognition of Berry, Pomegranate, Grape and Biophenols: A General Review. The Journal of Prevention of Alzheimer’s Disease (JPAD). http://dx.doi.org/10.14283/jpad.2018.21

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