journal articles
GLOBAL ALZHEIMER’S PLATFORM TRIAL READY COHORTS FOR THE PREVENTION OF ALZHEIMER’S DEMENTIA
R. Sperling, J. Cummings, M. Donohue, P. Aisen
J Prev Alz Dis 2016;3(4):185-187
With the now widely accepted view that preventing Alzheimer’s disease likely will require treatment in the earliest stages of disease, a number of secondary prevention trials have been launched. Recruiting sufficient numbers of participants for these trials represents a major roadblock. To address this barrier, the Global Alzheimer’s Platform Trial Ready Cohorts for Preclinical and Prodromal Alzheimer’s Dementia (GAP TRC-PAD) has created an efficient and sustainable recruitment system for upcoming secondary prevention trials. The initial goal of this effort will be to identify a large number of potential participants, rapidly screen these individuals using an adaptive risk algorithm, and ultimately identify 1000 preclinical and 1000 prodromal participants for the first GAP clinical trials. Embedded in this effort will be the development and validation of web-based cognitive and functional assessments for use in future trials. In combination with other GAP infrastructure, this initiative will provide an integrated platform to support efficient clinical trials not only in the pre-dementia space, but across all disease stages
CITATION:
R. Sperling ; J. Cummings ; M. Donohue ; P. Aisen (2016): Global Alzheimer’s Platform Trial Ready Cohorts for the Prevention of Alzheimer’s Dementia. The Journal of Prevention of Alzheimer’s Disease (JPAD). http://dx.doi.org/10.14283/jpad.2016.108