journal articles
ANALYSIS OF THE RELATIONSHIP OF COGNITIVE IMPAIRMENT AND FUNCTIONAL IMPAIRMENT IN MILD ALZHEIMER’S DISEASE IN EXPEDITION 3
H. Liu-Seifert, E. Siemers, K. Sundell, M. Mynderse, J. Cummings, R. Mohs, P. Aisen
J Prev Alz Dis 2018;5(3):184-187
BACKGROUND: Clinical progression of Alzheimer’s disease is characterized by impairment in cognition and function.
OBJECTIVE: To assess the relationship between cognitive and functional impairment in mild Alzheimer’s disease.
DESIGN: Spearman’s rank correlations between cognitive and functional measures were calculated. Autoregressive cross-lagged panel analyses were used to determine the temporal relationship between cognitive and functional decline.
SETTING: Post-hoc analysis of clinical trial data.
PARTICIPANTS: Placebo-treated patients with mild Alzheimer’s disease from the Phase 3 solanezumab study EXPEDITION 3.
INTERVENTION: Placebo
MEASUREMENTS: Cognitive and functional measures were assessed at baseline and at six post-baseline time points through Week 80.
RESULTS: Correlation between cognitive and functional measures was 0.41 at baseline and 0.65 at Week 80. Autoregressive cross-lagged panel analysis demonstrated that cognitive impairment preceded and predicted subsequent functional decline, but functional scores did not predict cognitive outcomes.
CONCLUSIONS: This study supports the hypothesis that functional impairment predictably follows cognitive decline in mild Alzheimer’s disease dementia.
CITATION:
H. Liu-Seifert ; E. Siemers ; K. Sundell ; M. Mynderse ; J. Cummings ; R. Mohs ; P. Aisen (2018): Analysis of the Relationship of Cognitive Impairment and Functional Impairment in Mild Alzheimer’s Disease in EXPEDITION 3. The Journal of Prevention of Alzheimer’s Disease (JPAD). http://dx.doi.org/10.14283/jpad.2018.22